With the rapid development of the pharmaceutical industry in recent years, cleaning the traditional fluidized bed has been a great challenge for the pharmaceutical industry. Fluidized beds have been widely used in processes such as granulation, coacervation, suspension coating, pelletizing, powder or solution layer coating.
In the pharmaceutical industry, we are constantly developing new spray products, many of which are specially customized and produced to achieve special requirements, a good nozzle requires precise control of the spray particles, which can not only improve product quality and processing efficiency, but also It can help customers increase operating time and reduce installation and maintenance time. Among them, the use of nozzles is critical.
Granulation spray drying
The fluidized bed distributes the binder or coating liquid onto the surface of the fluidized powder or pellet through several two-flow nozzles, and third-party low-pressure air from the air inlet creates a particle-free space around each nozzle. In this way, the use of lower pressures ensures better control of the granulation process. A good process design can reduce the number of nozzles when the pellets are sprayed and coated; in granulation, the spray particles are required to be evenly distributed, and compressed air is also required for atomization.
Cleaning-in-place and cleaning-in-place
Filter cleaning is currently done by placing in a plastic bag, moving to a clean room, manual or ultrasonic cleaning. This method of removing only part of the equipment components to the cleaning room for cleaning, while most of the rest are still cleaned in place, is called cleaning in place. If cleaning in place cannot be achieved, it will increase the work intensity and the chance of contamination.
In order to be able to complete the cleaning-in-place without removing any parts, it is necessary to realize the true cleaning-in-place of the fluidized bed through a specially designed cleaning procedure. Cleaning in place will completely solve the cross-contamination problem and shorten the overall cleaning time to 3~4 hours.
This cleaning-in-place requires a cleaning station for cleaning the fluidized bed and specially designed nozzles for cleaning the bed and sleeve filters. When cleaning is done after production, each filter can move up and down, there is a set of nozzles on the top of the filter, which can spray liquid to clean the filter, and the power of the spray can drive the filter to rotate, so that every fold of the filter is fully cleaned . At the same time, the nozzle located at the top of the tower sprays the cleaning liquid into the filter, and flushes the filter to ensure the cleanliness of the filter. The nozzles at the top of the column can also be moved up and down to clean the rest of the fluidized bed. Nozzle located at the bottom of the intake cavity to clean the fish scale screen and the intake cavity. The cleaning liquid can choose city water, detergent or hot and cold pure water according to the product characteristics. Cleaning systems can be designed to be fully automated without manual intervention, which facilitates verification of cleaning procedures.
• Spray drying nozzle, use pressure spray to reduce clogging, adjustable spray particle size, good abrasion resistance can prolong service life.
• Hydraulic atomizing nozzles are designed at the bottom and top of the fluidized bed for spraying, mixing and granulation.
• Tank cleaning nozzles are mainly used for cleaning equipment such as sanitary containers.