April 12, 2022

Cleaning method of pharmaceutical liquid dispensing tank

The liquid dispensing tank has different names according to different uses. It is used in the pharmaceutical liquid dispensing system. In the food and dairy industry, some are called mixing tanks, preparation tanks or aseptic liquid mixing tanks. According to the volume of the dosing tank, it can be divided into laboratory dosing tank, pilot-scale dosing tank, and large dosing tank. According to whether it can be moved, it can be divided into fixed dosing tank and mobile dosing tank, and some can also be dismantled. Liquid dispensing tank. According to the different stirring forms, there are magnetic stirring liquid dosing tanks, stirring blade liquid dosing tanks, and buffer liquid dosing tanks. According to different structures, it can be divided into single-layer liquid dispensing tank, thermal insulation stirring liquid dispensing tank, and three-layer thermal insulation liquid dispensing tank.

CYCO Fixed Cleaning Spray Ball

Maintenance methods and precautions for cleaning of pharmaceutical dosing tanks

CYCO Fixed Cleaning Spray Ball
The working principle of CIP system cleaning ball:
the fixed spray ball sprays a lot of water columns through a large number of small holes to clean the inner wall of the tank

The CIP cleaning system can ensure a certain cleaning effect and improve the safety of products; save operation time and increase efficiency; save labor and ensure operational safety; save energy such as water, steam, and reduce detergent consumption; production equipment can be large-scale and automated High level; prolong the service life of production equipment. The mechanism of action of CIP cleaning The chemical energy is mainly generated by the chemical reagents added to it, which is the main factor determining the cleaning effect. Generally, manufacturers can choose detergents according to the nature and degree of pollution of the cleaning object, the material of composition, water quality, the selected cleaning method, cost and safety. Commonly used detergents are acid, alkaline and sterilizing detergents.

The advantages of acid and alkaline detergents are: can kill all microorganisms; remove organic matter better.
Disadvantages are: strong irritation to the skin; poor washability.

The advantages of sterilants are: rapid bactericidal effect and effective against all microorganisms; generally non-toxic after dilution; not affected by water hardness; forming a film on the surface of the equipment; easy to measure the concentration; easy to measure;
Disadvantages are: special taste; requires certain storage conditions; different concentrations of sterilization effect are very different; easy to freeze when the temperature is low; improper usage will cause side effects; mixed with dirt The sterilization effect is significantly reduced; when spilled, it is easy to stain the environment and leave traces .

The acid in the acid-base detergent refers to 1%-2% nitric acid solution, and the alkali refers to 1%-3% sodium hydroxide used at 65℃-80℃. The disinfectant is a commonly used chlorine-based disinfectant, such as sodium hypochlorite. Under a certain flow of heat energy, the higher the temperature, the smaller the viscosity coefficient and the larger the Reynolds number (Re). The rise of temperature can usually change the physical state of the dirt, accelerate the chemical reaction speed, and increase the solubility of the dirt, which is convenient for the impurity solution to fall off during cleaning, thereby improving the cleaning effect and shortening the cleaning time. The magnitude of kinetic energy is measured by Re.

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